Clusterin in the eye: An old dog with new tricks at the ocular surface

Clusterin in the eye: An old dog with new tricks at the ocular surface

First described in 1983, the multifunctional protein CLU (clusterin) is expressed throughout the body, including in the eye.  CLU's homeostatic activities are well documented, however its roles in health and disease are still not well understood.  CLU protein is localized to the apical layers of the ocular surface epithelia and is also present in tears.  CLU prevents and ameliorates ocular surface disease in a preclinical model for dry eye by a remarkable sealing mechanism.  CLU could serve as a novel biotherapeutic for dry eye disease.

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